Determining the Provincial and National Burden of Influenza-Associated Severe Acute Respiratory Illness in South Africa Using a Rapid Assessment Methodology.
Identifieur interne : 000371 ( Main/Exploration ); précédent : 000370; suivant : 000372Determining the Provincial and National Burden of Influenza-Associated Severe Acute Respiratory Illness in South Africa Using a Rapid Assessment Methodology.
Auteurs : Jillian Murray [États-Unis] ; Adam Cohen [États-Unis] ; Sibongile Walaza [Afrique du Sud] ; Michelle Groome [Afrique du Sud] ; Shabir Madhi [Afrique du Sud] ; Ebrahim Variava [Afrique du Sud] ; Kathleen Kahn [Ghana] ; Halima Dawood [Afrique du Sud] ; Stefano Tempia [Afrique du Sud] ; Akhona Tshangela [Afrique du Sud] ; Marietje Venter [Afrique du Sud] ; Daniel Feikin [États-Unis] ; Cheryl Cohen [Afrique du Sud]Source :
- PloS one [ 1932-6203 ] ; 2015.
Descripteurs français
- KwdFr :
- MESH :
- Wicri :
- geographic : Afrique du Sud.
English descriptors
- KwdEn :
- Cost of Illness, HIV Seropositivity (complications), Hospitalization (statistics & numerical data), Humans, Incidence, Influenza, Human (complications), Influenza, Human (epidemiology), Models, Biological, Sentinel Surveillance, Severe Acute Respiratory Syndrome (complications), Severe Acute Respiratory Syndrome (epidemiology), South Africa.
- MESH :
- geographic : South Africa.
- complications : HIV Seropositivity, Influenza, Human, Severe Acute Respiratory Syndrome.
- epidemiology : Influenza, Human, Severe Acute Respiratory Syndrome.
- statistics & numerical data : Hospitalization.
- Cost of Illness, Humans, Incidence, Models, Biological, Sentinel Surveillance.
Abstract
Local disease burden data are necessary to set national influenza vaccination policy. In 2010 the population of South Africa was 50 million and the HIV prevalence was 11%. We used a previously developed methodology to determine severe influenza burden in South Africa. Hospitalized severe acute respiratory illness (SARI) incidence was calculated, stratified by HIV status, for four age groups using data from population-based surveillance in one site situated in Gauteng Province for 2009-2011. These rates were adjusted for each of the remaining 8 provinces based on their prevalence of risk factors for pneumonia and healthcare-seeking behavior. We estimated non-hospitalized influenza-associated SARI from healthcare utilization surveys at two sites and used the percent of SARI cases positive for influenza from sentinel surveillance to derive the influenza-associated SARI rate. We applied rates of hospitalized and non-hospitalized influenza-associated SARI to census data to calculate the national number of cases. The percent of SARI cases that tested positive for influenza ranged from 7-17% depending on age group, year, province and HIV status. In 2010, there were an estimated 21,555 total severe influenza cases in HIV-uninfected individuals and 13,876 in HIV-infected individuals. In 2011, there were an estimated 29,892 total severe influenza cases in HIV-uninfected individuals and 17,289 in HIV-infected individuals. The incidence of influenza-associated SARI was highest in children <5 years and was higher in HIV-infected than HIV-uninfected persons in all age groups. Influenza virus was associated with a substantial amount of severe disease, especially in young children and HIV-infected populations in South Africa.
DOI: 10.1371/journal.pone.0132078
PubMed: 26154306
Affiliations:
- Afrique du Sud, Ghana, États-Unis
- Gauteng, Maryland, Région du Grand Accra
- Accra, Johannesbourg
- Université du Witwatersrand
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Centers for Disease Control and Prevention, Atlanta, United States of America.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Centers for Disease Control and Prevention, Pretoria, South Africa; Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Walaza, Sibongile" sort="Walaza, Sibongile" uniqKey="Walaza S" first="Sibongile" last="Walaza">Sibongile Walaza</name><affiliation wicri:level="1"><nlm:affiliation>National Institute of Communicable Diseases, Johannesburg, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>National Institute of Communicable Diseases, Johannesburg</wicri:regionArea><wicri:noRegion>Johannesburg</wicri:noRegion></affiliation></author><author><name sortKey="Groome, Michelle" sort="Groome, Michelle" uniqKey="Groome M" first="Michelle" last="Groome">Michelle Groome</name><affiliation wicri:level="1"><nlm:affiliation>Medical Research Council: Respiratory and, Meningeal Pathogens Research Unit, Johannesburg, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Medical Research Council: Respiratory and, Meningeal Pathogens Research Unit, Johannesburg</wicri:regionArea><wicri:noRegion>Johannesburg</wicri:noRegion></affiliation></author><author><name sortKey="Madhi, Shabir" sort="Madhi, Shabir" uniqKey="Madhi S" first="Shabir" last="Madhi">Shabir Madhi</name><affiliation wicri:level="4"><nlm:affiliation>National Institute of Communicable Diseases, Johannesburg, South Africa; Medical Research Council: Respiratory and, Meningeal Pathogens Research Unit, Johannesburg, South Africa; Schools of Public Health and Pathology, University of the Witwatersrand, Johannesburg, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>National Institute of Communicable Diseases, Johannesburg, South Africa; Medical Research Council: Respiratory and, Meningeal Pathogens Research Unit, Johannesburg, South Africa; Schools of Public Health and Pathology, University of the Witwatersrand, Johannesburg</wicri:regionArea><orgName type="university">Université du Witwatersrand</orgName><placeName><settlement type="city">Johannesbourg</settlement><region type="region" nuts="2">Gauteng</region></placeName></affiliation></author><author><name sortKey="Variava, Ebrahim" sort="Variava, Ebrahim" uniqKey="Variava E" first="Ebrahim" last="Variava">Ebrahim Variava</name><affiliation wicri:level="1"><nlm:affiliation>Klerksdorp Tshepong Hospital, Klerksdorp, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Klerksdorp Tshepong Hospital, Klerksdorp</wicri:regionArea><wicri:noRegion>Klerksdorp</wicri:noRegion></affiliation></author><author><name sortKey="Kahn, Kathleen" sort="Kahn, Kathleen" uniqKey="Kahn K" first="Kathleen" last="Kahn">Kathleen Kahn</name><affiliation wicri:level="4"><nlm:affiliation>Schools of Public Health and Pathology, University of the Witwatersrand, Johannesburg, South Africa; University of KwaZulu-Natal, Durban, South Africa; Umeå University, Umeå, Sweden; INDEPTH Network, Accra, Ghana.</nlm:affiliation><country xml:lang="fr">Ghana</country><wicri:regionArea>Schools of Public Health and Pathology, University of the Witwatersrand, Johannesburg, South Africa; University of KwaZulu-Natal, Durban, South Africa; Umeå University, Umeå, Sweden; INDEPTH Network, Accra</wicri:regionArea><placeName><settlement type="city">Accra</settlement><region nuts="2">Région du Grand Accra</region></placeName><orgName type="university">Université du Witwatersrand</orgName></affiliation></author><author><name sortKey="Dawood, Halima" sort="Dawood, Halima" uniqKey="Dawood H" first="Halima" last="Dawood">Halima Dawood</name><affiliation wicri:level="1"><nlm:affiliation>University of KwaZulu-Natal, Durban, South Africa; Pietermaritzburg Metropolitan Hospital Complex, Pietermaritzburg, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>University of KwaZulu-Natal, Durban, South Africa; Pietermaritzburg Metropolitan Hospital Complex, Pietermaritzburg</wicri:regionArea><wicri:noRegion>Pietermaritzburg</wicri:noRegion></affiliation></author><author><name sortKey="Tempia, Stefano" sort="Tempia, Stefano" uniqKey="Tempia S" first="Stefano" last="Tempia">Stefano Tempia</name><affiliation wicri:level="1"><nlm:affiliation>Centers for Disease Control and Prevention, Pretoria, South Africa; National Institute of Communicable Diseases, Johannesburg, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Centers for Disease Control and Prevention, Pretoria, South Africa; National Institute of Communicable Diseases, Johannesburg</wicri:regionArea><wicri:noRegion>Johannesburg</wicri:noRegion></affiliation></author><author><name sortKey="Tshangela, Akhona" sort="Tshangela, Akhona" uniqKey="Tshangela A" first="Akhona" last="Tshangela">Akhona Tshangela</name><affiliation wicri:level="1"><nlm:affiliation>National Institute of Communicable Diseases, Johannesburg, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>National Institute of Communicable Diseases, Johannesburg</wicri:regionArea><wicri:noRegion>Johannesburg</wicri:noRegion></affiliation></author><author><name sortKey="Venter, Marietje" sort="Venter, Marietje" uniqKey="Venter M" first="Marietje" last="Venter">Marietje Venter</name><affiliation wicri:level="1"><nlm:affiliation>Centers for Disease Control and Prevention, Atlanta, United States of America; National Institute of Communicable Diseases, Johannesburg, South Africa; Zoonoses Research Unit, Department of Medical Virology, University of Pretoria, Pretoria, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>Centers for Disease Control and Prevention, Atlanta, United States of America; National Institute of Communicable Diseases, Johannesburg, South Africa; Zoonoses Research Unit, Department of Medical Virology, University of Pretoria, Pretoria</wicri:regionArea><wicri:noRegion>Pretoria</wicri:noRegion></affiliation></author><author><name sortKey="Feikin, Daniel" sort="Feikin, Daniel" uniqKey="Feikin D" first="Daniel" last="Feikin">Daniel Feikin</name><affiliation wicri:level="1"><nlm:affiliation>Johns Hopkins International Vaccine Access Center, Baltimore, Maryland, United States of America; Centers for Disease Control and Prevention, Atlanta, United States of America.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Johns Hopkins International Vaccine Access Center, Baltimore, Maryland, United States of America; Centers for Disease Control and Prevention, Atlanta</wicri:regionArea><wicri:noRegion>Atlanta</wicri:noRegion></affiliation></author><author><name sortKey="Cohen, Cheryl" sort="Cohen, Cheryl" uniqKey="Cohen C" first="Cheryl" last="Cohen">Cheryl Cohen</name><affiliation wicri:level="4"><nlm:affiliation>National Institute of Communicable Diseases, Johannesburg, South Africa; Schools of Public Health and Pathology, University of the Witwatersrand, Johannesburg, South Africa.</nlm:affiliation><country xml:lang="fr">Afrique du Sud</country><wicri:regionArea>National Institute of Communicable Diseases, Johannesburg, South Africa; Schools of Public Health and Pathology, University of the Witwatersrand, Johannesburg</wicri:regionArea><orgName type="university">Université du Witwatersrand</orgName><placeName><settlement type="city">Johannesbourg</settlement><region type="region" nuts="2">Gauteng</region></placeName></affiliation></author></analytic><series><title level="j">PloS one</title><idno type="eISSN">1932-6203</idno><imprint><date when="2015" type="published">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Cost of Illness</term><term>HIV Seropositivity (complications)</term><term>Hospitalization (statistics & numerical data)</term><term>Humans</term><term>Incidence</term><term>Influenza, Human (complications)</term><term>Influenza, Human (epidemiology)</term><term>Models, Biological</term><term>Sentinel Surveillance</term><term>Severe Acute Respiratory Syndrome (complications)</term><term>Severe Acute Respiratory Syndrome (epidemiology)</term><term>South Africa</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Coût de la maladie</term><term>Grippe humaine ()</term><term>Grippe humaine (épidémiologie)</term><term>Hospitalisation ()</term><term>Humains</term><term>Incidence</term><term>Modèles biologiques</term><term>République d'Afrique du Sud</term><term>Surveillance sentinelle</term><term>Syndrome respiratoire aigu sévère ()</term><term>Syndrome respiratoire aigu sévère (épidémiologie)</term><term>Séropositivité VIH ()</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>South Africa</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>HIV Seropositivity</term><term>Influenza, Human</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Hospitalization</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Grippe humaine</term><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cost of Illness</term><term>Humans</term><term>Incidence</term><term>Models, Biological</term><term>Sentinel Surveillance</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Coût de la maladie</term><term>Grippe humaine</term><term>Hospitalisation</term><term>Humains</term><term>Incidence</term><term>Modèles biologiques</term><term>République d'Afrique du Sud</term><term>Surveillance sentinelle</term><term>Syndrome respiratoire aigu sévère</term><term>Séropositivité VIH</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Afrique du Sud</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Local disease burden data are necessary to set national influenza vaccination policy. In 2010 the population of South Africa was 50 million and the HIV prevalence was 11%. We used a previously developed methodology to determine severe influenza burden in South Africa. Hospitalized severe acute respiratory illness (SARI) incidence was calculated, stratified by HIV status, for four age groups using data from population-based surveillance in one site situated in Gauteng Province for 2009-2011. These rates were adjusted for each of the remaining 8 provinces based on their prevalence of risk factors for pneumonia and healthcare-seeking behavior. We estimated non-hospitalized influenza-associated SARI from healthcare utilization surveys at two sites and used the percent of SARI cases positive for influenza from sentinel surveillance to derive the influenza-associated SARI rate. We applied rates of hospitalized and non-hospitalized influenza-associated SARI to census data to calculate the national number of cases. The percent of SARI cases that tested positive for influenza ranged from 7-17% depending on age group, year, province and HIV status. In 2010, there were an estimated 21,555 total severe influenza cases in HIV-uninfected individuals and 13,876 in HIV-infected individuals. In 2011, there were an estimated 29,892 total severe influenza cases in HIV-uninfected individuals and 17,289 in HIV-infected individuals. The incidence of influenza-associated SARI was highest in children <5 years and was higher in HIV-infected than HIV-uninfected persons in all age groups. Influenza virus was associated with a substantial amount of severe disease, especially in young children and HIV-infected populations in South Africa.</div></front></TEI><affiliations><list><country><li>Afrique du Sud</li><li>Ghana</li><li>États-Unis</li></country><region><li>Gauteng</li><li>Maryland</li><li>Région du Grand Accra</li></region><settlement><li>Accra</li><li>Johannesbourg</li></settlement><orgName><li>Université du Witwatersrand</li></orgName></list><tree><country name="États-Unis"><region name="Maryland"><name sortKey="Murray, Jillian" sort="Murray, Jillian" uniqKey="Murray J" first="Jillian" last="Murray">Jillian Murray</name></region><name sortKey="Cohen, Adam" sort="Cohen, Adam" uniqKey="Cohen A" first="Adam" last="Cohen">Adam Cohen</name><name sortKey="Feikin, Daniel" sort="Feikin, Daniel" uniqKey="Feikin D" first="Daniel" last="Feikin">Daniel Feikin</name></country><country name="Afrique du Sud"><noRegion><name sortKey="Walaza, Sibongile" sort="Walaza, Sibongile" uniqKey="Walaza S" first="Sibongile" last="Walaza">Sibongile Walaza</name></noRegion><name sortKey="Cohen, Cheryl" sort="Cohen, Cheryl" uniqKey="Cohen C" first="Cheryl" last="Cohen">Cheryl Cohen</name><name sortKey="Dawood, Halima" sort="Dawood, Halima" uniqKey="Dawood H" first="Halima" last="Dawood">Halima Dawood</name><name sortKey="Groome, Michelle" sort="Groome, Michelle" uniqKey="Groome M" first="Michelle" last="Groome">Michelle Groome</name><name sortKey="Madhi, Shabir" sort="Madhi, Shabir" uniqKey="Madhi S" first="Shabir" last="Madhi">Shabir Madhi</name><name sortKey="Tempia, Stefano" sort="Tempia, Stefano" uniqKey="Tempia S" first="Stefano" last="Tempia">Stefano Tempia</name><name sortKey="Tshangela, Akhona" sort="Tshangela, Akhona" uniqKey="Tshangela A" first="Akhona" last="Tshangela">Akhona Tshangela</name><name sortKey="Variava, Ebrahim" sort="Variava, Ebrahim" uniqKey="Variava E" first="Ebrahim" last="Variava">Ebrahim Variava</name><name sortKey="Venter, Marietje" sort="Venter, Marietje" uniqKey="Venter M" first="Marietje" last="Venter">Marietje Venter</name></country><country name="Ghana"><region name="Région du Grand Accra"><name sortKey="Kahn, Kathleen" sort="Kahn, Kathleen" uniqKey="Kahn K" first="Kathleen" last="Kahn">Kathleen Kahn</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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